The New Vaccines
Physicochemical rules must be followed for the development of fully-protective, chemically-synthesized vaccines. We have identified most of these principles or rules for the prototype disease (malaria) for developing a panel of functionally-relevant, specifically modified, high activity binding peptides (mHABPs) attaching to host cells, thereby inducing sterile protective immunity in the experimental Aotus monkey model. These principles include a polypropyline II – left handed-like (PPIIL) 26.5 ± 3.5 A° distance between aminoacids fitting into Pockets 1 to 9 of Class II molecules’ peptide binding region (PBR), an appropriate charge and volume of residues fitting into these molecules’ Pockets 1, 4, 6 and 9, as well as specific rotamer orientation of residues contacting the T-cell receptor that must be preceded by specific β turns in the N-terminal regions as well as positively charged residues in positions p10 or p11.These principles or rules have led to developing long-lasting, protection-inducing multi-epitope, multistage, minimal subunit-based, chemically-synthesized vaccines or effective immune protection-inducing, synthetic protein structures.
Speaker: Prof. Manuel Elkin Patarroyo M. MD.
Institution: Fundación Instituto de Inmunología de Colombia – FIDIC. Bogotá, Colombia